Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomised trial
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چکیده
منابع مشابه
Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing Caesarean section.
BACKGROUND The cardiovascular effects of oxytocin in animal models and women undergoing Caesarean section include tachycardia, hypotension and decrease in cardiac output. These can be sufficient to cause significant compromise in high-risk patients. We aimed to find a simple way to decrease these risks whilst retaining the benefits of oxytocin in decreasing bleeding after delivery. Method. We r...
متن کاملHaemodynamic Effects of Oxytocin as Intravenous Bolus or Infusion on Women Undergoing Caesarean Section
Oxytocin is commonly used in obstetric practice as uterotonic drug for induction and augmentation of labour (1) and remains the drug of choice for facilitating uterine contractions during vaginal and operative delivery (2). Several regimens of oxytocin have been tested during cesarean delivery (CD) with variable wanted (uterotonic) and unwanted (cardiovascular) effects (3-7). When given as a ra...
متن کاملEfficacy and safety of carbetocin applied as an intravenous bolus compared to as a short-infusion for caesarean section: study protocol for a randomised controlled trial
BACKGROUND The two most commonly used uterotonic drugs in caesarean section are oxytocin and carbetocin, a synthetic oxytocin analogue. Carbetocin has a longer half-life when compared to oxytocin, resulting in a reduced use of additional uterotonics. Oxytocin is known to cause fewer cardiovascular side effects when administered as a short-infusion compared to as an intravenous bolus. Based on t...
متن کاملMinimum effective bolus dose of oxytocin during elective Caesarean delivery.
BACKGROUND The aim of this study was to determine the lowest effective bolus dose of oxytocin to produce adequate uterine tone (UT) during elective Caesarean delivery (CD). METHODS Seventy-five pregnant patients undergoing elective CD under spinal anaesthesia were randomized to receive oxytocin (0.5, 1, 3, 5 units) or placebo. UT was assessed by a blinded obstetrician as either adequate or in...
متن کاملOBSTETRICS Haemodynamic effects of repeated doses of oxytocin during Caesarean delivery in healthy parturients
Results. Twenty women required a second bolus of oxytocin 5 u. Both the first and the second doses produced clinically and statistically significant haemodynamic changes, but the haemodynamic changes induced by the second dose were smaller than after the first dose. The mean maximal change in CO after the first and second doses were 94% (CI 70–117) and 42% (CI 33–52), respectively (P,0.0001), a...
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ژورنال
عنوان ژورنال: BJOG: An International Journal of Obstetrics & Gynaecology
سال: 2011
ISSN: 1470-0328
DOI: 10.1111/j.1471-0528.2011.03022.x